MatriDerm® Decision Tree
On the basis of 6 general questions the decision tree guides you to the suitable procedure and MatriDerm® product you can use for a complex wound reconstruction.
What is MatriDerm®?
MatriDerm® is a unique collagen-elastin-template, which serves as a dermal replacement scaffold and can be applied both in a One- and Multi-Step Procedure.
Open porous matrix
No chemical cross-linking
Native collagen fibers
Contains elastin
Clinical Benefits
MatriDerm® Scientific Rationale
MatriDerm® is able to preserve closeness to human dermis, accelerate cell invasion, cell elongation and proliferation and limit myofibroblast formation and contraction1. This scientific performance is as a result of our Advanced CryoSafe® Method which gently preserves the native structure with no chemical crosslinking.2
1. Dill V and Moergelin M, Int Wound J 2020;17(3):618-630
2. Böhm S et al.; Materials 2017; 10(9), 1086
ACCELERATES
In an animal AV-Loop model number of new formed blood vessels were analyzed in wounds treated with either with MatriDerm® Dermal Matrix or competitor product. MatriDerm Dermal Matrix accelerates revascularization.
LIMITS
In vitro analysis of the formation of myofribroblast phenotype by α-SMA staining. MatriDerm® Dermal Matrix limits myofibroblast formation compared to competitor products1. Myofibroblast formation is associated with wound contraction2 . Limited wound contraction is observed with MatriDerm.3,4,5
MatriDerm® Clinical Performance
Ensures Active Healing1
In diabetic foot ulcers the combination of MatriDerm with STSG lead to a shorter healing period compared to STSG alone.
Cost Effective
In an RCT the total surgical treatment costs of Full-thickness wounds treated with STSG alone or with MatriDerm Dermal Matrix and STSG were analyzed. The costs do not differ significantly.
Improves Quality of Wound Healing1
Long term follow-up study of an intra-individual comparison of patients treated with STSG alone and with MatriDerm Dermal Matrix and STSG to analyze different skin parameter after 12 years of treatment. It demonstrate a long lasting effect on scar quality even after 12 years by the use of MatriDerm Dermal Matrix compared to STSG alone.
MatriDerm® Indications
Pre-operative: Hyperextension of the MCP joint – function is considerably limited.
Courtesy of L. Kamolz, MD, Graz, Austria
Fist closure is not possible.
Courtesy of L. Kamolz, MD, Graz, Austria
Intra-operative: Complete excision of the scar tissue.
Courtesy of L. Kamolz, MD, Graz, Austria
Intra-operative: The scar tissue – laid back onto the wound bed for the photo – reveals the dimension of the scar contraction, the skin deficit and the substantial functional limitation.
Courtesy of L. Kamolz, MD, Graz, Austria
Long-term follow-up: Normal function of the hand…
Courtesy of L. Kamolz, MD, Graz, Austria
Long-term follow-up: Normal function of the hand…
Long-term follow-up: Normal function of the hand…
Courtesy of L. Kamolz, MD, Graz, Austria
A 42-year old male presented with a flame burn on chest and neck (60 % TBSA).This is a challenging region due to high incidents of contractions, so high elasticity is very important.
Courtesy of E. Dantzer, MD, Toulon, France
The wound was carefully debrided to ensure a vital wound bed. MatriDerm® (1 mm) was applied to the wound bed
Courtesy of E. Dantzer, MD, Toulon, France
A split-thickness skin graft (STSG) was placed on top of MatriDerm® in a One-Step Procedure.
Courtesy of E. Dantzer, MD, Toulon, France
Two and five years post-operatively, the grafted area showed very good elasticity and skin colour.
Courtesy of E. Dantzer, MD, Toulon, France
The good functional outcome was demonstrated by the unlimited extension of the neck
Courtesy of E. Dantzer, MD, Toulon, France
This case demonstrates that MatriDerm® can be used successfully in demanding region like the neck with excellent aesthetic and functional outcome.
Courtesy of E. Dantzer, MD, Toulon, France
This case demonstrates that MatriDerm® can be used successfully in demanding region like the neck with excellent aesthetic and functional outcome.
Courtesy of E. Dantzer, MD, Toulon, France
This patient (who is an Orthopedic Surgeon) underwent emergency debridement for necrotizing fasciitis of the lower leg.
COURTESY OF I YOUNIS, MBBCH, MRCS (ENG), MSC, FRCS (PLAST), LONDON, UK.
In order to save his leg and life almost all the skin, soft tissue and fascia of his lower leg were debrided including the vascular (paratenon layer) of the medial and lateral gastrocnemius tendons.
COURTESY OF I YOUNIS, MBBCH, MRCS (ENG), MSC, FRCS (PLAST), LONDON, UK.
NPWT with instillation and dwell time (NPWTi-d) was applied following debridement for further cleansing of the wound and to form a layer of granulation tissue over the musculature producing a smoother and more even wound bed surface prior to the application of the dermal template.
COURTESY OF I YOUNIS, MBBCH, MRCS (ENG), MSC, FRCS (PLAST), LONDON, UK.
NPWT with instillation and dwell time (NPWTi-d) was applied following debridement for further cleansing of the wound and to form a layer of granulation tissue over the musculature producing a smoother and more even wound bed surface prior to the application of the dermal template.
COURTESY OF I YOUNIS, MBBCH, MRCS (ENG), MSC, FRCS (PLAST), LONDON, UK.
Following this a Two-Step Procedure was used by bolstering two A4 size 2mm MatriDerm® Dermal Matrix templates with NPWT and a non-adherent silicone interface layer with the aim of obliterating the soft tissue cavity which was greater than 5mm. The MatriDerm® Dermal Matrix template was also used to bridge the exposed gastrocnemius tendons.
COURTESY OF I YOUNIS, MBBCH, MRCS (ENG), MSC, FRCS (PLAST), LONDON, UK.
The first NPWT dressing change showed good integration of MatriDerm® Dermal Matrix.
COURTESY OF I YOUNIS, MBBCH, MRCS (ENG), MSC, FRCS (PLAST), LONDON, UK.
After several changes of NPWT filling of the soft tissue defect was achieved with reduced area of exposed tendons lacking paratenon.
COURTESY OF I YOUNIS, MBBCH, MRCS (ENG), MSC, FRCS (PLAST), LONDON, UK.
To bridge the remaining area of tendons which lacked vascularity a smaller size 1 mm MatriDerm® Dermal Matrix was applied as a One-Step Procedure with a Split-Thickness Skin Graft at the same time that was bolstered with NPWT.
COURTESY OF I YOUNIS, MBBCH, MRCS (ENG), MSC, FRCS (PLAST), LONDON, UK.
Two years postoperatively, the reconstruction of this lower leg with Two-Step Procedure 2 mm and One-Step Procedure 1 mm MatriDerm® Dermal Matrix shows no soft tissue indentation with intact and stable skin over the tendons with full return to function.
The patient has returned to work as a full time Orthopedic Surgeon.
COURTESY OF I YOUNIS, MBBCH, MRCS (ENG), MSC, FRCS (PLAST), LONDON, UK.
A 60-year-old male with diabetic foot syndrome and a history of obesity and coronary heart disease, presented with a gangrenous right foot.
COURTESY OF D LUEDI, MD, LANGENTHAL, SWITZERLAND.
An emergency bedside debridement was performed and IV antibiotics were started. At the following surgical debridement, the 5th metatarsal bone was resected. The wound was further debrided with the use of maggots. The wound bed was prepared with gauze-based Negative Pressure Wound Therapy (NPWT), which was set at 120 mmHg.
COURTESY OF D LUEDI, MD, LANGENTHAL, SWITZERLAND.
At the time of wound closure, the excess granulation tissue was removed and a dry sheet of 1 mm MatriDerm® was applied on the wound bed, MatriDerm® was then moistened with Ringer’s lactate.
COURTESY OF D LUEDI, MD, LANGENTHAL, SWITZERLAND.
A split-thickness skin graft immediately followed in a One-Step Procedure.
COURTESY OF D LUEDI, MD, LANGENTHAL, SWITZERLAND.
A non-adherent wound contact layer was placed over the skin graft and the graft was fixated with NPWT. After 7 days, NPWT was ceased and the skin graft demonstrated good take rate and healing. The wound was dressed with fatty gauze dressings.
COURTESY OF D LUEDI, MD, LANGENTHAL, SWITZERLAND.
Two months post-operatively, wound healing had progressed well.
COURTESY OF D LUEDI, MD, LANGENTHAL, SWITZERLAND.
Three months post op, the wound showed stable wound closure and the patient was able to walk with a diabetic shoe.
COURTESY OF D LUEDI, MD, LANGENTHAL, SWITZERLAND.
Six months post op, the wound showed stable wound closure and the patient was able to walk with a diabetic shoe.
COURTESY OF D LUEDI, MD, LANGENTHAL, SWITZERLAND.
Day 0: R0-excision of the carcinoma
Courtesy of N. Lilgenau, MD, Vienna, Austria
The intra-operative view showing the dry application of the collagen elastin template MatriDerm® 1mm on the wound bed fixed with normal sutures
Courtesy of N. Lilgenau, MD, Vienna, Austria
Immediate coverage of collagen elastin template MatriDerm® with a fenestrated split-thickness skin graft in a One-Step Procedure. Afterwards the wound dressing was performed by using fatty gauze, bulky dressing and tight bandaging.
Courtesy of N. Lilgenau, MD, Vienna, Austria
Day 14 p. o.: The post-operative view shows a complete wound closure with a full graft take of the transplant
Courtesy of N. Lilgenau, MD, Vienna, Austria
Follow-up 7 months: The reconstructed skin demonstrated excellent elasticity and pliability,
characteristics …
Courtesy of N. Lilgenau, MD, Vienna, Austria
… seen by the facial movement…
Courtesy of N. Lilgenau, MD, Vienna, Austria
… seen by the facial movement of this skin region.
Courtesy of N. Lilgenau, MD, Vienna, Austria
Surgical approach at the musculus flexor digitorum brevis, preparation and release of the adhesive tissue.
COURTESY OF U GRAF, MD, ZURICH, SWITZERLAND.
Gentle pull through of a small sheet of dry 1 mm MatriDerm.
COURTESY OF U GRAF, MD, ZURICH, SWITZERLAND.
Wrapping of the tendon.
COURTESY OF U GRAF, MD, ZURICH, SWITZERLAND.
COURTESY OF U GRAF, MD, ZURICH, SWITZERLAND.
Final View before wound closure. No reoccurrence of the claw toe and the patient no longer has an incorrect position and is able to wear his own shoes.
COURTESY OF U GRAF, MD, ZURICH, SWITZERLAND.
Consecutive patient underwent female-to-male affirming surgery. On the preoperative day, the flap was drawn on the non-dominant hand and an Allen test was performed to confirm vascular support from the ulnar artery. Under a tourniquet, the flap was raised distally to proximally and care was taken to meticulously clip all vessel branches.
The radial sensory nerve (asterisk) was identified, dissected, and spared. The flap was raised in a subfascialplane and care was taken to include the proximal sensory nerves, veins and axial pedicle.
Courtesy of W. Watfa, MD, Lausanne, Switzerland. Watfa et al.
At this donor site, the flexor carpi radialis and brachioradialis muscle bellies were approximated and sutured together before skin graft coverage, providing a better recipient site for the graft. In addition, the flexor carpi radialis epitendineum was preserved to maximally support graft take.
Courtesy of W. Watfa, MD, Lausanne, Switzerland. Watfa et al.
After a meticulous haemostasis, two MatriDerm® sheets (1 mm) were placed over the defect. An STSG was harvested using an air dermatome of 0.2 mm thickness and fibrin glue1 was sprayed on the STSG. The STSG was directly placed over collagen elastin matrix in a one-step procedure. A vacuum-assisted closure 2 was applied for 1 week at continuous -125 mm Hg pressure.
Courtesy of W. Watfa, MD, Lausanne, Switzerland. Watfa et al.
4-year after surgery the aesthetic and functional outcome demonstrate very good parameter in sensory and functional skin texture, quality and cosmetic appearance. The skin could be pinched more than 1 cm.
Courtesy of W. Watfa, MD, Lausanne, Switzerland. Watfa et al.
This case shows the good sensory and functional results achieved by using MatriDerm® at the donor site after RFFF harvesting in transgender surgery.
Courtesy of W. Watfa, MD, Lausanne, Switzerland. Watfa et al.
Courtesy of W. Watfa, MD, Lausanne, Switzerland. Watfa et al.
Portfolio
- Flexible
- More collagen*
- Stronger*
- Conformable at complicated anatomic areas
- Easy to use, handle and apply
- All sizes available in 3 different thicknesses
| Ref. No | Size | |
|---|---|---|
| A4 | 83440 - 200 | 210 x 297 x 1mm |
| 83460 - 200 | 210 x 297 x 2mm | |
| 83470 - 200 | 210 x 297 x 3mm | |
| A6 | 83441 - 200 | 105 x 148 x 1mm |
| 83461 - 200 | 105 x 148 x 2mm | |
| 83471 - 200 | 105 x 148 x 3mm | |
| A8 | 83442 - 200 | 52 x 74 x 1mm |
| 83462 - 200 | 52 x 74 x 2mm | |
| 83472 - 200 | 52 x 74 x 3mm | |
| A9 | 83443 - 200 | 37 x 52 x 1mm |
| 83463 - 200 | 37 x 52 x 2mm | |
| 83473 - 200 | 37 x 52 x 3mm |
- For highly exuding wounds
- More collagen*
- Stronger*
- Easy to use, handle and apply
- All sizes available in 3 different thicknesses
| Ref. No | Size | |
|---|---|---|
| A4 | 83410 - 200 | 210 x 297 x 1mm |
| 83420 - 200 | 210 x 297 x 2mm | |
| 83430 - 200 | 210 x 297 x 3mm | |
| A6 | 83411-200 | 105 x 148 x 1mm |
| 83421-200 | 105 x 148 x 2mm | |
| 83431-200 | 105 x 148 x 3mm | |
| A8 | 83412 - 200 | 52 x 74 x 1mm |
| 83422 - 200 | 52 x 74 x 2mm | |
| 83432 - 200 | 52 x 74 x 3mm | |
| A9 | 83413 - 200 | 37 x 52 x 1mm |
| 83423 - 200 | 37 x 52 x 2mm | |
| 83433 - 200 | 37 x 52 x 3mm |
- CE-certified since 2005
- Available in 2 different thicknesses
- Available in 4 different sizes
| Ref. No | Size | |
|---|---|---|
| A4 | 83500 - 200 | 210 x 297 x 1mm |
| 83400 - 200 | 210 x 297 x 2mm | |
| A6 | 83403 - 200 | 105 x 148 x 1mm |
| 83401 - 200 | 105 x 148 x 2mm | |
| A8 | 83404 - 200 | 52 x 74 x 1mm |
| A9 | 83405 - 200 | 37 x 52 x 1mm |
Patient Information
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