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What is MatriDerm?

Native Collagen Fibres

  • Improved wound healing through native collagen26,27,28

  • Improved cell migration and reconstruction of new dermis7,28 

No Chemical Cross-Linking

  • No-release of cell-toxic substances 
  • Improved cellular growth29,30

Elastin

  • Triggers early vascularization21,22,23,31 
  • Improved elasticity of new skin20,23,24,25 
  • Enables early physical therapy and rehabilitation9,37
      

Over 148 Peer-Reviewed Articles

  • Over 70 of these articles prove MatriDerm Dermal Matrix’s efficiency in an immediate grafting procedure

Native Collagen

MariDerm dermal matrix preserves the structure and porosity of native collagen1,2,13.

What are the benefits of this native collagen structure?

  • Structural & biochemical properties of native collagen2,13 
  • High similarity (97%) to human dermis2,13  
  • Fast cell attachment, elongation and migration2 
  • Fast revascularization21,22,23,36
  • Fast cell proliferation2,13

Where can MatriDerm help?

MatriDerm is indicated for use in the treatment of wounds, including:

Partial & Full thickness skin defects

  • Burns
  • Trauma
  • Chronic wounds
  • Exposed structures
  • Surgical wounds
    - Dermatological diseases
    - Cancer excisions
    - Donor sites

Adhesion Prevention

  • Nerves*
  • Tendons*

Mucosal defects

* Not indicated for MatriDerm pluS

Bibliography

MatriDerm Mode of Action

Fast Fibroblast Proliferation13 

MatriDerm leads to higher cellular proliferation compared to other dermal matrices.

Fast Revascularization36 

MatriDerm leads to faster revascularization compared to other dermal matrices.


Accelerated Regeneration4 

MatriDerm achieves fast matrix integration. Within 1 week, 95 % of the matrix is integrated, allowing clinicians to clos wound much earlier than other dermal substitutes4.

Why is Speed Important?

Wound healing follows a series of clearly defined and timed phases. Delays or disruptions in this process can lead to:

  • Impaired healing4,5 
  • Wound chronicity via stagnant inflammation4-6 
  • Disorganized collagen deposition5,7 
  • Fibrosis and hypertrophy4,5,8 

MatriDerm supports early wound closure⁴˒⁶ and enables clinicians to close wounds early.
By reducing the time a wound remains exposed, MatriDerm can help:

  • Improve clinical outcomes³²˒³³˒³⁴.
  • Support patient recovery³³.
  • Optimise healthcare resources³⁵.

MatriDerm gives time back to clinicians, hospitals, and patients. Because healing shouldn't wait.

Benefits for patients

The impact of MatriDerm in one image 

Burn by friction: MatriDerm was applied on the hand, where the burn was deeper, and the full wound was immediately covered with STSG

How to get there?

Guided Neodermis Formation10,11,27,28

Neodermis refers to newly regenerated dermal tissue that forms within a dermal regeneration matrix. By limiting the participation of myofibroblasts, MatriDerm promotes neodermis formation instead of scar tissue formed through contraction. Histological sections of tissue healed with MatriDerm present strong similarities to healthy human dermis, whereas scar tissue shows structural characteristics that compromise the quality and function of the skin.

Restored Skin Elasticity12

The body's ability to produce elastin is highest during early infancy and declines with age. Upon wound formation, the body produces only a small amount of compensatory elastin, remaining far below the levels found in healthy tissue. By applying MatriDerm, the elastic response of the skin resembles much more that of the healthy dermis.

Reduced Myofibroblast Population2

An extended pro-inflammatory profile leads to myofibroblast-driven contraction, fibrosis, and scarring. MatriDerm supports fibroblast-driven regeneration and prevents myofibroblast-driven contraction and scarring. As a consequence, MatriDerm significantly reduces the formation of myofibroblasts compared to other dermal matrices2,13.

Benefits for Clinicians / Hospitals

Low Infection & Complication Rate

MatriDerm is associated with low infection rates compared to other dermal matrices5-8,14-16. Two key factors can contribute to this:

  • Its fast integration4 into the tissue allows early wound closure5,6, which provides defense against infections by restoring the barrier function. 

  • Its fast re-vascularization21,22,36 allows the patient’s immune system to defend the wounded area while healing progresses. 

Shorter Hospitalization & Lower Costs9

With MatriDerm, even complex wounds can be closed in half the time compared to STSG alone, releasing the patient significantly earlier. 

Time saving transforms into cost savings17-19 by: 

  • Reducing the need of medication, analgesic and hospital resources like bedding and personnel.  
  • Reducing number of operations through immediate closure and lower complications rate  
  • Providing stable regeneration that remains aesthetic and functional even in the long term (e.g. scar revision due to hypertrophy) 

1. Böhm S, et al. Materials (Basel). 2017;10(9):1086. 
2. Dill V, Mörgelin M. Int Wound J. 2020;17(3):618–630. 
3. Hill DM. Burns Open. 2025;9:100380. 
4. Koll KK, et al. Plast Reconstr Surg. 2025;156(4):509e–520e. 
5. Pauchot J, et al. Dermatol Surg. 2012;39(1):43–50. 
6. Wallner B, et al. Eur J Trauma Emerg Surg. 2022;49(1):551–557. 
7. Phillips GSA, et al. Ann Burns Fire Disasters. 2020;33(3):245–252. 
8. Heimbach DM, et al. J Burn Care Rehabil. 2003;24(1):42–48. 
9. Krasteva ES, et al. Albanian J Trauma Emerg Surg. 2023;7(2):1240–1244. 
10. Kilbad. Normal Epidermis and Dermis with Intradermal Nevus 10x. Wikimedia Commons; 2008. 
11. Buzea C, et al. Juniper Online J Orthop Orthoplastic Surg. 2020;2(5):86–89. 
12. Kamolz LP. Presentation at the ISBI Meeting; Montreal; 2008. 
13. Hong JP, et al. Int Wound J. 2025;22(1): e70108. 
14. Bargues L, et al. Ann Chir Plast Esthet. 2009;54(6):533–539. 
15. Liu X, et al. J Burn Care Res. 2019;40(1)– S209–S210. 
16. Lo CH, et al. Burns. 2022;48(3):529–538. 
17. Childers C, et al. JAMA Surg. 2017;153(4):e176233. 
18. Morozzo U, et al. Indian J Surg. 2015;77(Suppl 3):1180–1187. 

19. Jeon et al. Arch Plast Surg. 2013;40:403–408.
20. Bloemen MCT, et al. Plast Reconstr Surg. 2010;125(5):1450–1459. 
21. Geyer SH, et al. Ann Anat. 2015;197:3–10.  
22. Wiedner M, et al. Wound Repair Regen. 2014;22(6):749–754. 
23. Daamen WF, et al. Tissue Eng Part A. 2008;14(3):349–360. 
24. Haslik W, et al. J Plast Reconstr Aesthet Surg. 2010;63(2):360–364. 
25. Ryssel H, et al. Burns. 2008;34(1):93–97. 
26. Mörgelin M. Scanning electron microscopy images. Lund University, Sweden. 
27. de Vries HJ, et al. Wound Repair Regen. 1994;2(1):37–47. 
28. de Vries HJC, et al. Br J Dermatol. 1995;132(5):690–697. 
29. Killat J, et al. Int J Mol Sci. 2013;14(7):14460–14474. 
30. Wietbrock JO. Dissertation. Ludwig-Maximilians-Universität München; 2016. 
31.  Frueh FS, et al. J Invest Dermatol. 2017;137(1):217–227. 
32. Böttcher-Haberzeth S, et al. Pediatr Surg Int. 2012;28(2):171–177.
33. Dickson K, et al. J Burn Care Res. 2023;44(5):1100–1109.
34. Lempert M, et al. Langenbecks Arch Surg. 2022;407(1):327–335.
35. Hop MJ, et al. Burns. 2014;40(3):388–396.
36. Schmidt, VJ. et al. (2017) Ann Plast Surg. 79(1):92-100.
37. Haslik W, et al. Burns. 2007;33(3):364–368.

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